Uncover epigenetic mechanisms for deeper insights

Because Diagenode has been focusing exclusively on epigenomics for 20 years, we can provide high quality epigenomics products for chromatin studies. We developed a wide range of solutions for a variety of sample types and inputs, with an emphasis on low input technologies. All these are provided with what you need to be able to master chromatin analysis: user-friendly protocols as well as options for numerous validation steps and complete workflows.

ATAC-seq

Assessment of open chromatin regions at single-nucleotide resolution

• Highly efficient isolation of nuclei with optimized protocols for cells and tissues
• Accurate library amplification with an intermediate quantification step
• High tagmentation reproducibility using Diagenode proprietary Tagmentase (Tn5 transposase)
• Accurate sequencing data with unique dual indexes to mitigate index hoping

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iDeal CUT&Tag

Accurate low-input chromatin profiling

• Validated for histone and some non-histone proteins
• High efficiency using proprietary Diagenode pA-Tn5
• Accurate library amplification with an intermediate quantification step
• Monitoring of assay efficiency by qPCR
• Accurate sequencing data with unique dual indexes to mitigate index hoping

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Chromatin immunoprecipitation

Genome-wide mapping of DNA–protein interactions

Diagenode addresses specific research needs with a vast array of optimized ChIP

• ChIP-seq on histones: standard and low input
• ChIP-seq on transcription factors
• ChIP-seq on plants
• ChIP on FFPE samples
• ChIP-qPCR
• ChIPmentation

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Antibodies

Combine Diagenode antibodies with CUT&Tag and ChIP kits

• Validated in epigenetic applications, including ChIP, ChIP-seq, CUT&Tag
• Batch-specific validation data available on the website
• Guaranteed performance for tested applications

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