Megaruptor 3: Your partner in long-read sequencing

Get the robust and reproducible sequencing results you need. Eliminate shearing tubes and needles! Designed to provide simple, automated, and highly reproducible fragmentation of DNA, the Megaruptor 3 is essential.

• Reproducible shearing that surpasses needle shearing
• More flexible shearing range from 5 kb – 100 kb unlike shearing tubes
• Unmatched quality: Get the tight fragment distribution you need – unlike with needles or tubes
• High throughput: Process 1 to 12 samples
• Safe from contamination and clogs*
• Automated: Process without user input and without washing sequences

The Megaruptor 3 is unsurpassed for these applications:

• HiFi Sequencing
• de novo assembly
• Structural variant detection
• Microbial multiplexing

Excellent reproducibility achieved with the Megaruptor 3

The Megaruptor 3 provides excellent shearing results for HiFi sequencing and other long-read based applications. Test shears of E. coli K12 are shown. The amount of gDNA input was 0.5 μg in a volume of 100 μl. Fragment lengths generated averaged 10 kb in length. Femto Pulse analysis shows all 8 channels sheared within a variance of only 9%.